Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 12 0.0 0.559 0.156 0.147
biological_process el 12 0.235 0.955 0.73 0.237
biological_process ka 12 0.0 0.591 0.137 0.158
biological_process rf 12 0.0 0.559 0.156 0.147
cellular_component ct 12 0.001 0.535 0.2 0.166
cellular_component el 12 0.052 0.893 0.441 0.31
cellular_component ka 12 0.002 0.547 0.2 0.167
cellular_component rf 12 0.0 0.535 0.2 0.166
disease ct 5 0.002 0.945 0.32 0.398
disease el 5 0.013 0.764 0.39 0.307
disease ka 5 0.0 0.618 0.241 0.284
disease rf 5 0.002 0.934 0.317 0.394
genetic_interaction ct 8 0.017 0.954 0.506 0.29
genetic_interaction el 8 0.018 0.814 0.489 0.265
genetic_interaction ka 8 0.001 0.009 0.004 0.003
genetic_interaction rf 8 0.017 0.936 0.5 0.283
molecular_function ct 12 0.0 0.832 0.331 0.277
molecular_function el 12 0.178 0.785 0.459 0.177
molecular_function ka 12 0.0 0.817 0.304 0.271
molecular_function rf 12 0.0 0.832 0.327 0.275
pathway ct 3 0.055 0.202 0.123 0.06
pathway el 3 0.002 0.151 0.092 0.065
pathway ka 3 0.002 0.127 0.059 0.051
pathway rf 3 0.037 0.157 0.088 0.051
phenotype ct 5 0.001 0.234 0.08 0.093
phenotype el 5 0.273 0.763 0.591 0.179
phenotype ka 5 0.001 0.244 0.109 0.095
phenotype rf 5 0.001 0.234 0.08 0.093
protein_interaction ct 12 0.0 0.349 0.067 0.108
protein_interaction el 12 0.0 0.39 0.058 0.107
protein_interaction ka 12 0.0 0.032 0.006 0.009
protein_interaction rf 12 0.0 0.325 0.065 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 12 0.0 0.775 0.284 0.226
integration_mean_by_presence el 12 0.01 0.759 0.28 0.221
integration_mean_by_presence ka 12 0.0 0.724 0.193 0.21
integration_mean_by_presence rf 12 0.001 0.329 0.056 0.091
mean ct 12 0.0 0.724 0.24 0.246
mean el 12 0.001 0.5 0.182 0.152
mean ka 12 0.0 0.345 0.128 0.128
mean rf 12 0.001 0.328 0.054 0.09

CDF plots of non integrated kernels

CDF plots of integrated kernels